Peroxiredoxins Play an Important Role in the Regulation of Immunity and Aging in Drosophila

Aberrant immune responses and chronic inflammation can impose significant health risks promote premature aging. Pro-inflammatory are largely mediated via reactive oxygen species (ROS) reduction–oxidation reactions. A pivotal role in maintaining cellular redox homeostasis the proper control of redox-sensitive signaling belongs to a family antioxidant redox-regulating thiol-related peroxidases designated as peroxiredoxins (Prx). Our recent studies Drosophila have shown that Prxs play critical aging immunity. We identified two important ‘hubs’, endoplasmic reticulum (ER) mitochondria, where extracellular intracellular stress signals transformed into pro-inflammatory modulated by activity residing these organelles. Here, we found mitochondrial Prx intestinal epithelium is required prevent development barrier dysfunction, which drive systemic Using redox-negative mutant, demonstrated acts redox-dependent manner regulating age-related response. The hyperactive response observed flies under-expressing due abiotic but not changes bacterial content. This response, reduced lifespan phenotype, be rescued ER-localized Prx.